1,946 research outputs found

    The United States and the Law of the Sea After UNCLOS III

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    Measuring Expert Performance at Manually Classifying Domain Entities under Upper Ontology Classes

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    Classifying entities in domain ontologies under upper ontology classes is a recommended task in ontology engineering to facilitate semantic interoperability and modelling consistency. Integrating upper ontologies this way is difficult and, despite emerging automated methods, remains a largely manual task. Little is known about how well experts perform at upper ontology integration. To develop methodological and tool support, we first need to understand how well experts do this task. We designed a study to measure the performance of human experts at manually classifying classes in a general knowledge domain ontology with entities in the Basic Formal Ontology (BFO), an upper ontology used widely in the biomedical domain. We conclude that manually classifying domain entities under upper ontology classes is indeed very difficult to do correctly. Given the importance of the task and the high degree of inconsistent classifications we encountered, we further conclude that it is necessary to improve the methodological framework surrounding the manual integration of domain and upper ontologies

    Interactions of the fungicide 2-aminobutane with potato tubers

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    A synthetic route to 2-aminobutane (2-AB) was developed, which enabled the synthesis of specifically and uniformly 14C labelled 2-AB to be carried out. 14C labelling was employed as a means of detecting 2-aminobutane in tuber tissue samples. An analytical technique, based on acid extraction and scintillation counting, was developed for the determination of 2-AB residues in potato tubers. This allowed studies to be carried out on various factors influencing the efficiency of fumigation of potato tubers with 2-aminobutane.Using C 2-AB and a specially constructed small scale fumigation chamber, an investigation into the absorption and penetration of 2-AB into tubers was undertaken. The rate and extent of 2-AB absorption were studied, and also the effect of initial fumigant concentration and length of exposure period, on the final 2-AB residues in tubers. The depth of penetration was shown to be limited to the first 1 cm of tissue indicating that after initial absorption, the amine is firmly bound at or near the tuber surface. Thin layer chromatography of extracts from fumigated tubers,provided evidence which suggested that 2-AB is not metabolised by the tubers during the storage period.Damaged tubers were shown to absorb higher levels of 2-AB, and the effect of wound healing at different temperatures, prior to fumigation, was demonstrated. The preferential uptake of 2-aminobutane through tuberlenticels was highlighted as a possible cause of tuberto tuber variation in 2-AB residues. Studies showed that there was no appreciable loss of 2-AB from fumigated tubers during the storage period, and that transfer of 2-AB from tuber to tuber during air recirculation was very limited.The absorption of 2-AB by soil, straw and wood,was examined and identified as a likely sink for the amine fumigant, and this could contribute to the low 2-AB residues recorded for some commercial fumigations.A comparison of the antifungal activity of the optical isomers of 2-aminobutane, confirmed that the R-(-)- enantiomer was more active than the corresponding S-(+)- isomer, or racemic mixture, against the fungi responsible for gangrene and skin spot in potato tubers

    A Study of the Effect of Quinhydrone on the Time of Set of Silicic Acid Gells and of the Effect of Silicic Acid Gel on the Determination of pH by the Quinhydrone Electrode

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    The studies discussed in this report are supplementary to the work being done at Union College on silicic acid gels. In as much data has been taken in this work using pH as determined by the quinhydrone electrode, it was desired that a study be made of the effect of quinhydrone on the gel and of gel on the quinhydrone determinations. The pH of gels during their setting has been worked on and the first part of the experiment deals with the effect of quinhydrone on the time of set of silicic acid gel. Then it was desired to know wether a gel had any effect on the determination of the pH by means of the quinhydrone set up. It had been thought that there was no effect in either case but there was no experiemtnal evidence to show proof

    Design and synthesis of high affinity ligands for Cyclophilin A

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